Medicinal plants have been used for the treatment of health problems including fever. The polyhebral crud drug formulation (tablets) has been developed for the treatment of various diseases. The purpose of the present study was to formulate antipyretic polyhebral tablets by using well documented medicinal plants such as Andrographis paniculata (whole plant), Coleus aromaticus (whole plant), Tinospora cordifolia (stem), Zingiber officianale (rhizome) and Piper nigrum (ripe fruits). In this work, dried plants powder was used, which was obtained from different parts of five medicinal plants that have anti-pyretic effects. The polyherbal tablets were prepared by wet granulation method using single rotary tablet machine. All parameters related to physicochemical properties, microbial examination and trace metal of dried plants powder exhibited that these were within limits and can be used for the polyherbal tablet formulation. The granules of dried plants powders were prepared by wet granulation method using isopropyl alcohol. The blends were investigated for its flow properties as well as compressibility, which were found to be good. The polyherbal tablets were assessed for the colour, odour, thickness and diameter, with visual inspection for any defects on the tablets, weight variation, hardness, friability and in vitro disintegration time.
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